DIGITALIS & RELATED CARDIAC GLYCOSIDES Background
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چکیده
in the following notes the term digitalis is used to describe the entire group of cardiac glycosides a large number of plants contain cardiac glycosides, and these have been used by natives as arrow and ordeal poisons Squill was known to the ancient Egyptians and the Romans used it as a diuretic, heart tonic, emetic and rat poison Strophanthus was introduced by Sir Thomas Fraser in 1890 digitalis, or foxglove, was mentioned as early as 1250 in the writings of Welsh physicians and was not described botanically until 300 years later, by Fuschius who named it Digitalis purpurea in 1785 William Withering published "An Account of the Foxglove and Some of Its Medical Uses: with Practical Remarks on Dropsy and Other Diseases" John Ferrier (1799) was the first to ascribe the primary effect of digitalis to its action on the heart, relegating its diuretic action as secondary
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شناسایی گلیکوزیدهای قلبی گونه دیژیتال ایران به روش HPLC
Background and Purpose: Digitalis species and their cardiac glycosides are used in congestive heart failure (ÇHF) disease. Digitalis nervosa are grown only in the North regions of Ïran. Çardiac glycosides of other species are identified by HPLÇ procedure. Ïn this research, cardiac glycosides of Digitalis nervosa were identified. Materials and Methods: Ïn this research, methanol as solvent ...
متن کاملEffect of light and passage on cardiac glycoside production on cultured cell of Digitalis nervosa Steud & Hochst
Light is important for the production of metabolites by plant cell culture. It is therefore necessary to evaluate the light conditions with respect to exposure time. Both enhancement and inhibition have been observed depending on exposure time and species. Callus culture of D. nervosa was established and effect of light and passage on cardiac glycoside production was studied. In vitro cultures ...
متن کاملEffect of light and passage on cardiac glycoside production on cultured cell of Digitalis nervosa Steud & Hochst
Light is important for the production of metabolites by plant cell culture. It is therefore necessary to evaluate the light conditions with respect to exposure time. Both enhancement and inhibition have been observed depending on exposure time and species. Callus culture of D. nervosa was established and effect of light and passage on cardiac glycoside production was studied. In vitro cultures ...
متن کاملComparison of the Action of Ouabain on the Heart in Hypothyroid , Euthyroid and Hyperthyroid Dogs
• Although, it is assumed that digitalis glycosides are relatively ineffective in heart failure and atrial fibrillation associated with disorders of thyroid gland function," there is little experimental work to support this belief. Frye and Braunwald observed that administration of triiodothyronine to euthyroid and hypothyroid patients with chronic atrial fibrillation increased the dose of card...
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